Noise knows no limits

KIF4A knows its own limits

KIF4A knows its own limits N unes Bastos et al. describe how the ki-nesin motor KIF4A restricts its own activity during anaphase by recruiting the phosphatase PP2A-B56 to the central spindle. During mitosis, KIF4A limits the size of the central spindle by suppressing the growth of microtubules in the spindle midzone. The kinase Aurora B phosphorylates KIF4A to promote the kinesin's localization...

Electroporation Knows No Boundaries

The discovery of RNA interference (RNAi) has enabled several breakthrough discoveries in the area of functional genomics. The RNAi technology has emerged as one of the major tools for drug target identification and has been steadily improved to allow gene manipulation in cell lines, tissues, and whole organisms. One of the major hurdles for the use of RNAi in high-throughput screening has been ...

Noise knows no limits Noise Matters: The Evolution of Communication R. Haven Wiley (Harvard University Press, Cambridge and London; 2015) ISBN: 978-0-674-74412-7.

Independently, Attila Andics and colleagues at Budapest have also used functional MRI to compare dogs and humans and found that a voice area in the dog brain exists and responds to vocal stimuli in very similar ways to ours (Curr. Biol. (2014) 24, 574–578). Furthermore, Victoria Ratcliffe and David Reby from the University of Sussex at Falmer, UK, have reported behavioural studies suggesting th...

No body knows the trouble I've seen.

No Provable Limits Tòscientiic Knowledge'

In an article concerning problems that are impossible to solve exactly, but which can be computed in an average sense, J. F. Traub and H. Wozniakowski raised a challenge: \We believe it is time to up the ante and try to prove there are unanswerable scientiic questions. In other words, we would like to establish a physical GG odel's theorem.""1]. Out of this idea grew a workshop and computer sci...